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Publications

2023

Chemoenzymatic Synthesis: Cooperativity Enables Opportunity
 
Hessefort, L.Z.; Harstad, L.J.; Merker, K.R.; Ramos, L.P.T.; Biegasiewicz, K.F.*

ChemBioChem 2023, 24 (12), 1-17.

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Decarboxylative Bromooxidation of Indoles by a Vanadium Haloperoxidase
 
Wells, C.E.; Ramos, L.P.T.; Harstad, L.J.; Hessefort, L.Z.; Lee, H.J.; Sharma, M.;
Biegasiewicz, K.F.*

ACS Catal. 2023, 13 (7), 4622-4628.

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2022

A Radical-Relay Approach to Biocatalytic C–N Bond Formation
 
Tennant, J.J.; Biegasiewicz, K.F.* 

Chem Catalysis 2022, 2, 2448-2448.

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2020

Organic Chemistry: A Retrosynthetic Approach to a Diverse Field
 
Laura K.G. Ackerman-Biegasiewicz, Daniela M. Arias-Rotondo, Kyle F. Biegasiewicz, Elizabeth Elacqua, Matthew R. Golder, Laure V. Kayser, Jessica R. Lamb, Christine M. Le, Nathan A. Romero, Sidney M. Wilkerson-Hill, Dwight A. Williams

ACS Cent. Sci. 2020, 6 (11), 1845-1850.

Publications from Undergraduate, Graduate, and Postdoctoral Training

2021

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Harmann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, Todd K. Hyster*

J. Am. Chem. Soc. 2021, 143 (1), 97-102.

2020

Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

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Dr. Yuji Nakano, Michael J. Black, Andrew J. Meichan, Braddock A. Sandoval, Megan M. Chung, Dr. Kyle F. Biegasiewicz, Dr. Tianyu Zhu, Prof. Dr. Todd K. Hyster

Angew. Chem. Int. Ed. 2020, 59 (26), 10484-10488.

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Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases​

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Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory D. Scholes & Todd K. Hyster 
 

Nat. Chem. 2020, 12, 71–75.

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2019

Photoenzymatic Catalysis Enables Radical‐Mediated Ketone Reduction in Ene‐Reductases

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Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Dr. Kyle F. Biegasiewicz, Prof. Dr. Todd K. Hyster 

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Angew. Chem. Int. Ed. 2019, 58, 8714-8718.

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Photoexcitation of Flavoenzymes Enables a Stereoselective Radical Cyclization

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Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, Todd K. Hyster

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Science, 2019, 364, 1166-1169.

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Biocatalytic Hydrogen Atom Transfer: an Invigorating Approach to Free-Radical Reactions

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Yuji Nakano, Kyle F. Biegasiewicz, Todd K. Hyster

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Curr. Opin. Chem. Biol. 2019, 49, 16-24.

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2018

Catalytic Promiscuity Enabled by Photoredox Catalysis in Nicotinamide-Dependent Oxidoreductases

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Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller, & Todd K. Hyster

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Nat. Chem. 2018, 10, 770.

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Scalable Synthesis of (−)-Rasfonin Enabled by a Convergent Enantioselective α-Hydroxymethylation Strategy

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Robert K. Boeckman Jr.*, Justin M. Niziol, and Kyle F. Biegasiewicz

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Org. Lett. 2018, 20 (16), 5062–5065.

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Formaldehyde

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Arnel B. Concepcion, Hisashi Yamamoto, Robert K. Boeckman Jr., Kyle F. Biegasiewicz, Douglas J. Tusch

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e-EROS Encyc. Reagents Org. Synth. 2018.

Encyclopedia of Reagents for Organic Synthesis
2018-03-12 | encyclopedia-entry

2015

Organocatalyzed Direct Asymmetric α-Hydroxymethylation of Aldehydes

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Robert K. Boeckman, Jr., Douglas J. Tusch, and Kyle F. Biegasiewicz

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Org. Synth. 2015, 92, 320

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(S)-1,1-Diphenylprolinol Trimethylsilyl Ether

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 Robert K. Boeckman, Jr., Douglas J. Tusch, and Kyle F. Biegasiewicz

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Org. Synth. 2015, 92, 309.

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Organocatalytic Enantioselective α-Hydroxymethylation of Aldehydes: Mechanistic Aspects and Optimization

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Robert K. Boeckman, Jr., Kyle F. Biegasiewicz, Douglas J. Tusch, and John R. Miller

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J. Org. Chem. 2015, 80 (8), 4030-4045.

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Cubane: 50 Years Later

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Kyle F. Biegasiewicz, Justin R. Griffiths, G. Paul Savage, John Tsanaktsidis, and Ronny Priefer

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Chem. Rev. 2015, 115 (14), 6719.

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2014

Development of a General Approach to the Synthesis of a Library of Isoflavonoid Derivatives

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Kyle F. Biegasiewicz, James S. Gordon IV, Deana A. Rodriguez, Ronny Priefer

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Tetrahedron Lett. 2014, 55, 5210.

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2013

CHAPTER 5. Chemistry and Synthesis of Daidzein and its Methylated Derivatives: Formononetin, Isoformononetin, and Dimethyldaidzein

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Vincent M. Carroll, Jeffrey D. St. Denis, Kyle F. Biegasiewicz and Ronny Priefer

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Food Nutr. Compon. Focus 2013, 5 (isoflavones), 61.

Food and Nutritional Components in Focus

book-chapter

2012

Evaluation of a Chiral Cubane-Based Schiff Base Ligand in Asymmetric Catalysis Reactions

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Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage and Ronny Priefer

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Beilstein J. Org. Chem. 2012, 8, 1814.

2010

An Efficient Synthesis of Daidzein, Dimethyldaidzein, and Isoformononetin

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Kyle F. Biegasiewicz, Jeffrey D. St. Denis, Vincent M. Carroll, Ronny Priefer

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Tetrahedron Lett. 2010, 51, 4408.

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