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Chemoenzymatic Synthesis: Cooperativity Enables Opportunity
Hessefort, L.Z.; Harstad, L.J.; Merker, K.R.; Ramos, L.P.T.; Biegasiewicz, K.F.*

ChemBioChem 2023, 24 (12), 1-17.


Decarboxylative Bromooxidation of Indoles by a Vanadium Haloperoxidase
Wells, C.E.; Ramos, L.P.T.; Harstad, L.J.; Hessefort, L.Z.; Lee, H.J.; Sharma, M.;
Biegasiewicz, K.F.*

ACCatal. 2023, 13 (7), 4622-4628.

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A Radical-Relay Approach to Biocatalytic C–N Bond Formation
Tennant, J.J.; Biegasiewicz, K.F.* 

Chem Catalysis 20222, 2448-2448.

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Organic Chemistry: A Retrosynthetic Approach to a Diverse Field
Laura K.G. Ackerman-Biegasiewicz, Daniela M. Arias-Rotondo, Kyle F. Biegasiewicz, Elizabeth Elacqua, Matthew R. Golder, Laure V. Kayser, Jessica R. Lamb, Christine M. Le, Nathan A. Romero, Sidney M. Wilkerson-Hill, Dwight A. Williams

ACS Cent. Sci. 2020, 6 (11), 1845-1850.

Publications from Undergraduate, Graduate, and Postdoctoral Training


Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Harmann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, Todd K. Hyster*

J. Am. Chem. Soc. 2021, 143 (1), 97-102.


Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

Dr. Yuji Nakano, Michael J. Black, Andrew J. Meichan, Braddock A. Sandoval, Megan M. Chung, Dr. Kyle F. Biegasiewicz, Dr. Tianyu Zhu, Prof. Dr. Todd K. Hyster

Angew. Chem. Int. Ed. 202059 (26), 10484-10488.


Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases​

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory D. Scholes & Todd K. Hyster 

Nat. Chem2020, 12, 71–75.



Photoenzymatic Catalysis Enables Radical‐Mediated Ketone Reduction in Ene‐Reductases

Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Dr. Kyle F. Biegasiewicz, Prof. Dr. Todd K. Hyster 

Angew. Chem. Int. Ed. 2019, 58, 8714-8718.


Photoexcitation of Flavoenzymes Enables a Stereoselective Radical Cyclization

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, Todd K. Hyster

Science, 2019, 364, 1166-1169.


Biocatalytic Hydrogen Atom Transfer: an Invigorating Approach to Free-Radical Reactions

Yuji Nakano, Kyle F. Biegasiewicz, Todd K. Hyster

Curr. Opin. Chem. Biol. 2019, 49, 16-24.



Catalytic Promiscuity Enabled by Photoredox Catalysis in Nicotinamide-Dependent Oxidoreductases

Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller, & Todd K. Hyster

Nat. Chem. 2018, 10, 770.


Scalable Synthesis of (−)-Rasfonin Enabled by a Convergent Enantioselective α-Hydroxymethylation Strategy

Robert K. Boeckman Jr.*, Justin M. Niziol, and Kyle F. Biegasiewicz

Org. Lett. 2018, 20 (16), 5062–5065.

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Arnel B. Concepcion, Hisashi Yamamoto, Robert K. Boeckman Jr., Kyle F. Biegasiewicz, Douglas J. Tusch

e-EROS Encyc. Reagents Org. Synth2018.

Encyclopedia of Reagents for Organic Synthesis
2018-03-12 | encyclopedia-entry


Organocatalyzed Direct Asymmetric α-Hydroxymethylation of Aldehydes

Robert K. Boeckman, Jr., Douglas J. Tusch, and Kyle F. Biegasiewicz

Org. Synth. 2015, 92, 320

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(S)-1,1-Diphenylprolinol Trimethylsilyl Ether

 Robert K. Boeckman, Jr., Douglas J. Tusch, and Kyle F. Biegasiewicz

Org. Synth. 2015, 92, 309.

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Organocatalytic Enantioselective α-Hydroxymethylation of Aldehydes: Mechanistic Aspects and Optimization

Robert K. Boeckman, Jr., Kyle F. Biegasiewicz, Douglas J. Tusch, and John R. Miller

J. Org. Chem. 2015, 80 (8), 4030-4045.

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Cubane: 50 Years Later

Kyle F. Biegasiewicz, Justin R. Griffiths, G. Paul Savage, John Tsanaktsidis, and Ronny Priefer

Chem. Rev. 2015, 115 (14), 6719.

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Development of a General Approach to the Synthesis of a Library of Isoflavonoid Derivatives

Kyle F. Biegasiewicz, James S. Gordon IV, Deana A. Rodriguez, Ronny Priefer

Tetrahedron Lett. 2014, 55, 5210.

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CHAPTER 5. Chemistry and Synthesis of Daidzein and its Methylated Derivatives: Formononetin, Isoformononetin, and Dimethyldaidzein

Vincent M. Carroll, Jeffrey D. St. Denis, Kyle F. Biegasiewicz and Ronny Priefer

Food Nutr. Compon. Focus 2013, 5 (isoflavones), 61.

Food and Nutritional Components in Focus



Evaluation of a Chiral Cubane-Based Schiff Base Ligand in Asymmetric Catalysis Reactions

Kyle F. Biegasiewicz, Michelle L. Ingalsbe, Jeffrey D. St. Denis, James L. Gleason, Junming Ho, Michelle L. Coote, G. Paul Savage and Ronny Priefer

Beilstein J. Org. Chem. 2012, 8, 1814.


An Efficient Synthesis of Daidzein, Dimethyldaidzein, and Isoformononetin

Kyle F. Biegasiewicz, Jeffrey D. St. Denis, Vincent M. Carroll, Ronny Priefer

Tetrahedron Lett. 2010, 51, 4408.

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